1 ml contains active substance:
Ketoprofen 10 mg;
Excipients: benzyl alcohol, L-arginine, sodium chloride, water for injections.
KETOPRO-10 is non-steroidal anti-inflammatory drug (NSAID) that has an analgesic and antipyretic effect. Ketoprofen, which is part of the drug, is a derivative of propionic acid from the carboxylic acids group.
Mechanism of Ketoprofen action consists in inhibiting cyclooxygenase enzyme and suppression of the prostaglandin and thromboxane synthesis. Analgesic action of ketoprofen is associated with inhibition of bradykinin directly, which excites painful nerve endings and thereby provokes pain. Ketoprofen acts on the central nervous system, suppressing the perception of pain.
After intramuscular administration to dogs the maximum concentration in blood plasma is reached within 7-10 minutes, after subcutaneous administration – in 30-35 minutes, and in cats, after subcutaneous administration, it is 15-20 minutes. More than 98% of ketoprofen binds to plasma proteins and is concentrated in inflamed tissues. The drug is excreted from the body mainly with urine.
In recommended doses the preparation has no local irritating, sensitizing, mutagenic, carcinogenic, embryotoxic and teratogenic effects.
KETOPRO-10 is administered to dogs and cats for the treatment of inflammatory processes in acute, para-acute and chronic diseases of the musculoskeletal system (arthrosis, arthritis, trauma, dislocations, edema, herniated intervertebral discs).
Product is administered to dogs subcutaneously, intramuscularly or intravenously; to cats – only subcutaneously, at dose 0.2 ml per 1 kg of body weight once daily for 1-3 consecutive days. After one injection, therapy can be continued with oral ketoprofen at a dose of 1 mg/kg once daily for 3-4 days.
Do not use in animals with individual sensitivity to the components of the drug, stomach and duodenal ulcer, pronounced renal and hepatic failure, a tendency to hemorrhage and bleeding of the mucous membranes. If there are signs of hemorrhagic syndrome, immediately stop using the drug and apply coagulants.
Ketopro-10 should not be administered concomitantly with other non-steroidal anti-inflammatory drugs, glucocorticoids, diuretics and anticoagulants.
Do not mix with other medicines in one syringe.
Provide the animal with free access to drinking water throughout the treatment period.
Observe the rules of asepsis and secure fixation of the animal.
Persons who are allergic to the drug should avoid working with it.
Intramuscular injections sometimes cause a fleeting sense of irritation.
INTERACTION WITH OTHER DRUGS, AND OTHER FORMS OF INTERACTION
Ketoprofen can enhance the effect of anticoagulants and aggregation inhibitors, other NSAID and glucocorticoids. The concomitant use of ketoprofen can reduce the effectiveness of diuretics.
Ampoules of 1 and 2 ml, vials of glass mass or polymeric materials of 10, 50, 100.0 ml.
24 months. After first opening: 28 days if kept in dark place at +5° to +25°С.
** FOR USE IN VETERINARY MEDICINE!
Store in dark place, out of the reach of children at 5° to 25°С.