1 ml of preparation contains following active substances: Doxycycline hyclate – 100 mg, Tylosin tartrate – 100 mg; Additional ingredients.
Pharmadox is a complex drug formulation, which is composed of Doxycycline and Tylosin. Doxycycline is a semi-synthetic antibiotic of the tetracyclines group, acting on the ribosome of bacteria, inhibiting protein synthesis. Doxycycline has a broad spectrum of antimicrobial action against Gram-positive and Gram-negative bacteria (Staphylococcusspp., Diplococcus pneumoniaе, Streptococcus spp., Haemophilus influenzaе, E. coli,Pneumococci, Bacillus anthracis, Clostridium tetani, Clostridium perfringens, Listeriamonocytogenes, Actinomyces spp., Enterobacter spp., Klebsiella spp., Salmonella spp.,Shigella spp., Yersinia spp.), as well as against Mycoplasmas (Mycoplasma spp.), Rickettsiaspp. and Chlamydia. Doxycycline after oral administration is well absorbed in the digestive tract, reaching peak serum concentration in 2 h. Doxycycline penetrates well into the lungs, and therefore is effective during the treatment of respiratory infections. Tylosin is a member of the macrolide group of antibiotics, is active against Gram-positive and Gram-negative bacteria like Staphylococcus spp., Streptococcus spp., Diplococcusspp., Corynebacterium spp., Clostridium spp., Erysipelothrix rhusiopathiae, Neisseria spp.,
Bacteroides nodosus, Moraxella bovis, Pasteurella spp., Spirochetаspp. Mycoplasmas are especially susceptible to Tylosin (Mycoplasma gallisepticum, Mycoplasmahyopneumoniae, Mycoplasma synoviae, Mycoplasma meleagridis, Mycoplasmaagalactiae, Mycoplasma bovigenitalium), as well as Chlamydia and Rickettsia spp.Tylosin after oral administration is well absorbed, penetrates all inner organs and is maintained at a therapeutic level in the blood of animals and birds for 6-8 h. Bioavailability of tylosin does not change under the influence of food. Tylosin is excretedin the urine, bile and feces.
Calves, goats and lambs aged between 4 to 8 weeks, pigs: treatment of animals with septicemia and respiratory diseases (pneumonia, enzootic pneumonia, atrophic rhinitis, etc.), digestive tract (colibacillosis, salmonellosis) caused by pathogens, susceptible to Doxycycline and Tylosin.
Poultry (chickens, broilers, turkeys, replacements) - treatment of birds with colibacillosis, salmonellosis, chlamydia, septicemia and respiratory diseases caused by pathogens susceptible to Doxycycline and Tylosin.
ROUTES OF ADMINISTRATION AND DOSAGES
For treating animals the product is administered orally for 3-5 days, as follows:
Calves, lambs, kids: with food, drinking water or milk at a dose of 1 g per 10 kg of body weight once per day;
Pigs: with feed or drinking water at a dose of 1 g per 10 kg of body weight once per day;
Poultry: in feed or drinking water at a dose of 1 g per 10 kg of body weight, or 1 g per 1 liter of water.
Depending on severity of the disease the first dose can be increased up to 2 doses.
Prevention: use a half of the recommended therapeutic dose, duration - 3-5 days.
For meat – 8 days (swine and poultry) and 14 days (calves, lambs, kids), after last treatment. Meat received before this time should be disposed or fed to non-productive animals, depending on conclusion of veterinarian.
36 months. After first opening – 28 days if stored in dark place at +5 to +25° С.
Store in dry, dark places, out of the reach of children, at +5 to +25 С.