TERMONORM
COMPOSITION
1 g of powder contains an active substance:
Acetylsalicylic acid – 700 mg;
Excipients: sodium carbonate anhydrous, Aerosil.
PHARMACOLOGICAL PROPERTIES
ATC vet QN02B – other analgesics and antipyretics, QN02BA01 – acetylsalicylic acid.
Acetylsalicylic acid is a non-narcotic analgesic of the salicylates group. It has an anti-inflammatory, analgesic, antipyretic effect and prevents platelet aggregation, which shows its antiaggregant effect.
Acetylsalicylic acid inhibits cyclooxygenase (prostaglandin synthetase), which reduces the synthesis of prostaglandins and thromboxanes. Due to these effects, acetylsalicylic acid performs its analgesic, antipyretic, and anti-inflammatory function. Most cells can synthesize cyclooxygenase again, but platelets do not have this ability. Therefore, acetylsalicylic acid has an irreversible effect on platelet aggregation.
Salicylates and their metabolites are rapidly excreted by the kidneys through filtration and renal tubular secretion.
INDICATIONS
The drug is administered to calves, pigs and poultry (broiler chickens, breeding chickens, young-replacements) in pathological states accompanied by hyperthermia, inflammatory and pain syndrome of mild and moderate intensity of various genesis (including inflammatory), including fever, respiratory diseases, MMA-syndrome (metritis-mastitis-agalactia), rheumatoid arthritis, osteoarthritis, laminitis, muscle and postoperative pain, heat stress.
ROUTES OF ADMINISTRATION AND DOSAGES
Orally, for 3-5 days, at a dose of 1 g of the drug per 7 kg of the animal body weight (100 mg of acetylsalicylic acid per kg b.w.), per day with drinking water, or individually.
The required amount of the drug is pre-mixed with at least 10x volume of drinking water heated to temperature 35°C at least and stirred vigorously for 20-30 minutes until complete dissolution (dissolution is accompanied by intense foaming).
The resulting solution is given to calves individually, dividing the daily required volume into two receiving, and for pigs and poultry solution is added to the water intended for daily intake.
During treatment, poultry and pigs should receive only water containing the drug.
When using the drug with drinking water, the solution is prepared based on the required amount of drinking water (according to the norms of water intake for certain animal species and age categories), dose, and animals’ weight.
In general, you can guide by the following quantities:
• 1.5 kg of the drug per 1000 litres of potable water for pigs;
• 300-600 g of the drug per 1000 l of potable water for poultry.
A fresh solution of the drug should be prepared daily.
CONTRAINDICATIONS
Do not administer to animals with individual hypersensitivity to salicylates.
Do not administer to animals with diseases of the gastrointestinal tract, in particular with peptic ulcer disease.
Do not use in animals with coagulation disorders.
It should be used with caution in animals with severe hepatic insufficiency and decreased renal function.
It should be discontinued 2 weeks before surgery.
Do not administer to piglets less than 1 month of age.
Do not use in pregnant and lactating females.
Do not use together with drugs that alkalize or acidify the urine, together with tetracycline group antibiotics and aminoglycosides, corticosteroids, and other NSAIDs, diuretics: furosemide and spironolactone, digoxin, heparin, and other anticoagulants.
PRECAUTIONS
The drug is used in combination with etiotropic therapy.
Milk and eggs obtained from animals during treatment with acetylsalicylic acid are prohibited for human consumption.
Slaughter of the animals for meat is allowed at least 1 day after the last treatment. Meat received before the specified time should be disposed of or fed to non-productive animals, depending on the conclusion of the veterinarian.
SIDE EFFECTS
In some cases itching, vomiting, muscle tremors may occur. If adverse effects are identified, the drug should be discontinued.
PACKAGING AND PRESENTATION
Bags made of polyethylene or foil materials, and polymer containers of 10 g, 50 g, 100 g, 150 g, 200 g, 250 g, 500 g; 1 kg, 2 kg, 5 kg.
SHELF LIFE
24 months.
STORAGE CONDITIONS
Store in a dry, dark place, out of the reach of children, at +5 to +25° С.
Once the bag is opened: 28 days if stored in a dry, dark place at +5° to +25°С.