TOLTRASAN-50
COMPOSITION
1 ml of preparation contains active substance Toltrazuril – 50 mg; additional ingredients.
PHARMACOLOGICAL PROPERTIESM
Preparation contains an active substance Toltrazuril, derivative from group triazinetrione, of a broad spectrum against: Eimeria adenoides, E. alabamensis, E. arloingi, E. bovis, E. brunetti, E. maxima, E. meleagrimitis, E. mitis, E. necatrix, E. scarab, E. tenella, Isospora suis, Е.zuernii; and other species at all intracellular development stages.
Toltrazuril interferes with intracellular stages of Eimeria development, affecting merogony, micro- and macrogametes. It impedes process of Eimeria nucleus division and inhibits activity of mitochondria, which are responsible for respiratory metabolism.
In animals body, Toltrazuril is partially metabolized with formation of sulfone and sulfoxide derivatives. Subsequently it is almost entirely excreted with faeces in unchanged form or in form of toltrazuril sulfone or toltrazuril sulfoxide.
Product has no mutagenic, carcinogenic and teratogenic effects.
ADMINISTRATION
Prevention and treatment of young cattle, sheep, goats, pigs, rabbits and poultry (broilers, breeding poultry, replacement chickens, parent and broiler flocks, meat turkeys) in case of coccidiosis caused by Eimeria susceptible to Toltrazuril.
ROUTESOF ADMINISTRATION AND DOSAGES
Preparation is administered orally with drinking water individually or by group method at following doses:
ANIMAL SPECIES |
DOSAGE |
DURATION OFTREATMENT |
|---|---|---|
Calves, lambs, kids starting from 2 weeks |
0.3 ml / kg body weight |
Single administration |
Piglets at 3-5 days of life |
1.4 ml / kg body weight (not less than 1.5 ml and not more than 2 ml per animal) |
|
Rabbits starting from 4 weeks |
0,14 ml / kg body weight |
|
Poultry |
0.5 ml / 1 L drinking water (administer for 48 hours) or |
2 days |
During the treatment medicated water should be the only source of drinking water for poultry. In severe case of disease, if required, repeat treatment in 5 days. To maximize preventive effect and in order to reduce oocyst excretion into environment, especially in damaged by coccidiosis farms, the product is to be administered to before first signs of disease appear.
WITHDRAWAL PERIOD
Meat: 77 days (piglets), 63 days (calves), 70 days (rabbits), 14 days (poultry) after last treatment.
SHELF LIFE
24 months. After first opening – 14 days if stored in dark place at +5 to +25° С.
STORAGE CONDITIONS
Store in dry, dark places, out of the reach of children at +5 to +25° С.