INJECTABLE SUSPENSION, VIALS
DESCRIPTION
Suspension for injection from white to light-yellow color.
DESCRIPTION
Suspension for injection from white to light-yellow color.
COMPOSITION
1 ml of the drug contains an active substance:
• Ceftiofur (as Ceftiofur Hydrochloride) – 50 mg.
• Additional ingredients: Benzyl Alcohol, Butylhydroxytoluene, Butylhydroxyanisole, Propylene Glycol Dipracrylate/Dipaprate.
PHARMACOLOGICAL PROPERTIES
ATC vet QJ01 – antibacterial veterinary drugs for systemic use. QJ01DD90 – Ceftiofur.
• Ceftiofur is a 3rd generation Cephalosporin antibiotic. The mechanism of its bactericidal action consists in inhibiting the functional activity of the bacterial enzymes Transpeptidases and Carboxypeptidases, which are involved in the synthesis of the main component of the cell wall of microorganisms – peptidoglycan, which leads to a violation of the osmotic balance and the destruction of the bacterial cell.
• Ceftiofur has a broad spectrum of activity, and is effective against Gram-positive bacteria (Escherichia Coli, Pasteurella (Mannheimia) Haemolytica, P. Multocida, Haemophilus Somnus, Actinobacillus Pleuropneumoniae, Haemophilus Parasuis, Salmonella Choleraesuis, Klebsiela spp., Citrobacter spp., Enterobacter spp., Bacillus spp., Proteus spp., Fusobacterium Necrophorum, Salmonella Typhimurium), and Gram-negative microorganisms(Streptococcus Suis, S. Zooepidemicus, S. Equi, S. Agalactiae, S. Dysgalactiae, S. Bovis, Staphylococcus spp., Actinomyces Pyogenes), including β-lactamase producing strains.
INDICATIONS
Cattle: Treatment of animals with acute postpartum Metritis, Necrobacteriosis, as well as Respiratory diseases caused by microorganisms susceptible to Ceftiofur.
Dogs and Cats: Treatment of animals with diseases of the Genitourinary system (Endometritis) and Skin (Pyoderma) caused by microorganisms sensitive to Ceftiofur.
ROUTE OF ADMINISTRATION AND DOSAGE
Cattle:
• In the treatment of Respiratory Diseases – intramuscularly at a dose of 1 ml of the drug per 50 kg of body weight (equivalent to 1 mg of Ceftiofur per 1 kg of body weight) once a day for 3-5 days;
• In the treatment of acute Necrobacteriosis – intramuscularly at a dose of 1 ml of the drug per 50 kg of body weight (equivalent to 1 mg of Ceftiofur per 1 kg of body weight) once a day for 3 days;
• In the treatment of Acute Postpartum Metritis (in 10 days after calving) – subcutaneously at a dose of 1 ml of the drug per 50 kg of body weight (equivalent to 1 mg of Ceftiofur per 1 kg of body weight) once a day for 5 days.
Dogs, Cats
• Intramuscularly at a dose of 1.0 ml of the drug per 10 kg of body weight (equivalent to 5 mg of Ceftiofur per 1 kg of body weight) once a day for 5-10 days.
• The maximum recommended dose for a single injection for Cattle is 10 ml of the drug; for Dogs – 5 ml, for Cats and Dogs of small breeds – 1 ml.
CONTRAINDICATIONS
• Do not use in animals with hypersensitivity to Cephalosporins and other β-Lactam antibiotics, as well as to the components of the drug, as well as with known resistance of the pathogen to the active substance of the drug.
• Do not use concurrently with Tetracyclines, Macrolides, Chloramphenicol, And Lincosamides.
• Do not use it as a preventive measure for the incidence of retained placenta.
• Do not administer to animals with impaired renal function.
PRECAUTIONS
• The use of the drug should be based on determining the sensitivity of pathogens to Ceftiofur and taking into account local regulations.
• The safety of Ceftiofur use during pregnancy and lactation in target animal species has not been determined. It should be used only after a benefit/risk assessment by a responsible veterinarian.
• Before use, the drug must be thoroughly shaken.
• Injections must be done each time in different sites of the animal's body.
• Do not administer intravenously.
• Pain and temporary swelling may occur at the injection site.
• In some cases, allergic reactions are possible, which quickly disappear after discontinuation of the drug. Intoxication with an overdose is almost impossible. If allergic reactions occur, it is advisable to administer corticosteroids and adrenaline to animals.
WITHDRAWAL PERIOD
Slaughter of animals for meat is allowed after 8 days (Cattle) after the last treatment. The consumption of milk for human consumption is allowed without restrictions.
PACKAGE AND PRESENTATION
Vials made of dark glass or polymeric materials, closed with rubber stoppers, and sealed with aluminum caps of 10, 50, 100, 250, and 500 ml.
SHELF LIFE AND STORAGE CONDITIONS
Store in a dark place, out of the reach of children, at a temperature of 5 to 25°С.
Shelf life – 36 months. After the first opening of the bottle – 28 days when stored in a dry, dark place at a temperature of 5 to 25°С.
FOR VETERINARY USE ONLY!