Iveron-10

CLOSIVERON
ANTIPARASITIC INJECTABLE SOLUTION

COMPOSITION
1 ml of the preparation contains the active substance: Ivermectin – 8 mg, Closantel – 100 mg (equivalent to 108,9 mg Closantel Sodium Dihydrate); additional ingredients.

PHARMACOLOGICAL PROPERTIES
• CLOSIVERON is a combined preparation of broad antiparasitic activity, which is composed of Ivermectin and Closantel. The components of the product act synergistically by inhibiting the activity of enzymes, breaking metabolic processes in the body of parasites.
• Ivermectin belongs to compounds which are produced by microorganisms of the group Streptomyces avermitilis. Ivermectin has high efficiency, a broad spectrum of action (insecticidal, acaricidal and nematicidal activity), and has relatively low toxicity. Ivermectin stimulates the secretion of gamma-aminobutyric acid (GABA) in presynaptic neurons, which binds to specific receptors of nerve endings by increasing membrane permeability to chloride ions and inhibits the transmission of neuromuscular pulses. This causes paralysis and death of the parasites.
• The maximum concentration in the blood is achieved approximately in 4 hours. It is characterized by a high degree of binding to plasma proteins (93%). Penetrates into many tissues, in small amounts - into milk. Does not pass through the blood-brain barrier. It is metabolized in the liver, and excreted mainly with faeces. Half-life is 12-16 hours.
• Closantel is an antiparasitic agent structurally derived of salicylanilides, it has a lasting impact on endo- and ectoparasites. Closantel inhibits the phosphorylation process (formation of ATP) in the body of the parasite due to intervention in processes of transporting electrons, altering energy metabolism, which leads to the death of a parasite. Closantel is effective against trematodes (Fasciola Gigantica, Fasciola Hepatica); Gastrointestinal Nematodes (Bunostomum Spp., Haemonchus Contortus, Oesophagostomum Radiatum); Gadfly Larvae (Hypoderma Bovis, Hypoderma Lineatum, Oestrus Ovis); Scabies Mites (Psoroptes spp.) in Cattle, Sheep and Goats. Closantel is quickly absorbed after subcutaneous or intramuscular administration.
• The maximum concentration in the blood of the sheep is reached in 8-24 hours after administration, in the blood of Cattle in 24-48 hours. The half-life is about 12-15 days.
• The highest concentration of Closantel is detected in the liver, kidney and adipose tissue. Closantel intensively binds to plasma proteins and is practically not metabolized in the body of animals; more than 90% of it is excreted unchanged with feces. The drug is quickly absorbed from the injection site and penetrates into the organs and tissues of animals. The therapeutic concentration of the drug in animals is maintained for 10-12 days. The product in therapeutic doses has no embryotoxic and teratogenic effects.


ADMINISTRATION
TREATMENT OF CATTLE AFFECTED BY
Nematodes (Adult And Larval Stages) – Ostertagia Spp., Haemonchus Placei, Cooperia Spp., Oesophagostomum Radiatum, Trichostrongylus Spp., Strongyloides Papillosus, Bunostomum Phlebotomum, Toxocara Vitulorum, Trichuris Spp, Dictyocaulus Viviparus (Adult Stages), Nematodirus Spp.;
• Trematodes – Fasciola Spp.;
• Gadfly Larvae – Hypoderma Bovis. Hypoderma Lineatum;
• Scabies Mites – Psoroptes Bovis, Sarcoptes Bovis;
• Lice – Haematopinus Eurysternus.

TREATMENT OF SHEEP AND GOATS AFFECTED BY
• Nematodes (Adult And Larval Stages) – Ostertagia Spp., Haemonchus Contortus, Trichostrongylus Spp., Cooperia Spp., Oesophagostomum Spp., Nematodirus Spp., Bunostomum Spp., Chaberta Ovina, Chaberta Ovis, Trichuris Ovis; Dictyocaulus flaria, Protostrongylus Spp.;
• Trematodes – Fasciola Hepatica;
• Gadfly Larvae – Oestrus Ovis;
• Scabies Mites – Psoroptes Ovis, Sarcoptes Ovis;
• Sheep Keds – Melophagus Ovinus.

ROUTES OF ADMINISTRATION AND DOSAGES