ANTIPARASITIC INJECTABLE SOLUTION IVERMECTIN 1%
COMPOSITION
1 ml of the preparation contains the active substance Ivermectin – 10.0 mg;
PHARMACOLOGICAL PROPERTIES
• The active ingredient of the preparation is Ivermectin belonging to compounds that are produced by microorganisms of the group Streptomyces Avermitilis.
• The mechanism of product action on parasites is in Ivermectin stimulation of secretion of gamma-aminobutyric acid (GABA) in presynaptic neurons, which binds to specific receptors of nerve endings by increasing membrane permeability to chloride ions and blocking the transmission of neuromuscular pulses. It causes paralysis and death of parasites.
• Ivermectin has high efficiency and a broad spectrum of action (insecticidal, acaricidal and nematicidal activity) and has relatively low toxicity. Ivermectin is not effective against trematodes and tapeworms because GABA does not work at them as a peripheral neurotransmitter.
ADMINISTRATION
Treatment of Cattle and Sheep affected by helminthosis:
Cattle
• Gastrointestinal and Lung Nematodosis, caused by Nematodirus Helvetianus, Ostertagia Ostertagi, O. Lyrata; Bunostomum Trigonocephalum, B. Phlebotomum, Haemonchus Placei, Trichostrongylus Axei, Т. Colubriformis, Cooperia Pectinata, C. Punctata, Dictyocaulus Viviparus;
• Enthomosis – Hypoderma Bovis, Hypoderma Lineatum;Mange – Psoroptes Bovis, Sarcoptes Bovis, Chorioptes Bovis, Demodex Bovis; Lousiness Haematopinus Eurysternus, Linognathus Vituli etc.
Sheep
• Gastrointestinal And Lung Nematodosis, caused by Haemonchus Contortus, Ostertagia Circumcincta, Ostertagia Trifurcata, Trichostrongylus Sрр, Dictyocaulus filaria, Protostrongylusrufescens;Enthomosis – Hypoderma Bovis, H.Lineatum;Mange – Psoroptes Ovis, Sarcoptes Ovis, Chorioptes Ovis; Lousiness – Haematopinus Eurysternus, Linognathus Vituli etc.
ANIMAL SPECIES | DOSAGE | DURATION OF TREATMENT | ROUTE OF ADMINISTRATION |
---|---|---|---|
Cattle | 1.0 ml per 50 kg body weight | Once | Subcutaneously in the shoulder area. If the dose exceeds 10 ml, inject at several places. |
Sheep | 0.5 ml per 25 kg body weight | Once | Subcutaneously in the neck area. |
ROUTES OF ADMINISTRATION AND DOSAGES
• Early therapy of Cattle Hypodermosis (October-November) is recommended with a low dose of the preparation (1.5-2.0 ml per animal).
• In the treatment of Mange, Demodicosis, Chorioptosis administration of the preparation is repeated in 7-10 days in the same doses.
WITHDRAWAL PERIOD
Slaughter of Cattle and Sheep for Meat is allowed in 28 days after the last treatment.
PRECAUTIONS
• Do not apply to non-target species. Do not use concurrently with other anthelmintics.
• Do not treat weakened, exhausted animals and animals with infectious diseases.
• Do not administer the preparation to Cows during lactation, in first third part of pregnancy and 28 days before calving.
SHELF LIFE
24 months. After first opening – 14 days if stored in a dark place at +5 to +25° С.
STORAGE CONDITIONS
Store in a dry, dark place, out of the reach of children, at +5 to +25° С.