NON-STEROIDAL ANTI-INFLAMMATORY DRUG (NSAID)
TRANSPARENT LIQUID, COLOURLESS OR LIGHT YELLOW.
COMPOSITION
1 ml contains the active substance:
• Ketoprofen 100 mg;
• Excipients: Benzyl Alcohol, L-Arginine, Water for Injections.
PHARMACOLOGICAL PROPERTIES
• KETOPRO-100 is a non-steroidal anti-inflammatory drug (NSAID) that has an analgesic and antipyretic effect. Ketoprofen, which is part of the drug, is a derivative of propionic acid from the carboxylic acids group.
• The mechanism of Ketoprofen action consists in inhibiting cyclooxygenase enzyme and suppression of prostaglandin and thromboxane synthesis. The analgesic action of ketoprofen is associated with the inhibition of bradykinin directly, which excites painful nerve endings and thereby provokes pain.
• Ketoprofen acts on the central nervous system, suppressing the perception of pain. In horses, ketoprofen counteracts the effect of endotoxin and prevents the occurrence of an intestinal spasm caused by bradykinin.
• Ketoprofen is rapidly absorbed after intramuscular administration. The maximum concentration in blood plasma is reached within 30 to 60 minutes. Absolute bioavailability after intramuscular administration for Cattle is 90-100%, and for Horses – 70%.
• More than 98% of ketoprofen binds to plasma proteins and is concentrated in inflamed tissues. The drug is excreted from the body mainly with urine. In recommended doses, the preparation has no local irritating, sensitizing, mutagenic, carcinogenic, embryotoxic, and teratogenic effects.
ADMINISTRATION
KETOPRO-100 is administered to Cattle, Sport Horses and pigs for the treatment of inflammatory processes in acute and chronic diseases of the musculoskeletal system (Arthrosis, Arthritis, Dislocations, Edema, Tendovaginitis, Trauma), pain syndrome of various etiology (Traumatic and Postoperative Pain, Colic, Herniated Intervertebral Discs), and also as an antipyretic agent in diseases accompanied by fever and depressed state. Is used in combination with antibacterial drugs for the complex treatment of respiratory tract infections, purulent necrotic lesions of the lower limbs parts, and clinical forms of mastitis.
DOSAGE
Cattle: 3 ml of the drug per 100 kg of body weight once daily intravenously or intramuscularly for 3 consecutive days.
Horses: 1 ml of the drug per 45 kg of body weight once daily for 3-5 days. In the case of colic, one injection is enough, if reinjection is necessary, it is necessary to reassess the clinical state of the animal.
CONTRAINDICATIONS
Individual hypersensitivity to the components of the drug. Pronounced renal and hepatic failure.
• Ketopro-100 should not be administered concomitantly with other Non-Steroidal Anti-Inflammatory Drugs, Glucocorticoids, Diuretics, and Anticoagulants.
• Do not mix with other medicines in one syringe.
• It is not recommended to apply to horses intended for meat production.
• Is not applied to the Foals in the first month of life.
• Do not use in pregnant Mares.
• Do not use intra-arterially.
PRECAUTIONS
• Provide the animal with free access to drinking water throughout the treatment period.
• Observe the rules of asepsis and secure fixation of the animal.
• People who are allergic to the drug should avoid working with it.
• Intramuscular injections sometimes cause a fleeting sense of irritation. Horses may have an allergic reaction to the drug.
INTERACTION WITH OTHER DRUGS, AND OTHER FORMS OF INTERACTION
Ketoprofen can enhance the effect of Anticoagulants and Aggregation Inhibitors, other NSAID and Glucocorticoids. The concomitant use of Ketoprofen can reduce the effectiveness of Diuretics.
WITHDRAWAL PERIOD
Slaughter of Cattle for Meat is allowed after 5 days after the last treatment. The meat of animals, which were forcedly slaughtered before the expiration of this period, can be used for feeding fur-bearing animals or for the production of meat-bone meals. The milk of Cows can be used for food purposes without restrictions.
PACKAGE
Vials of glass mass or polymeric materials of 100.0 ml.
STORAGE CONDITIONS
Store in a dark place, out of the reach of children at 5° to 25°С.
SHELF LIFE
24 months. After first opening: 28 days if kept in dark place at +5° to +25°С.
FOR USE IN VETERINARY MEDICINE!