1 ml of the preparation contains the active substance:
Tilmicosin – 300 mg;
Excipients: Benzyl Alcohol, Propylene Glycol, Water For Injection.

АТС vet QJ01 – antibacterial veterinary drugs for systemic use. QJ01FA91 – Tilmicosin.
• Tilmicosin is a semi-synthetic antibiotic of the Macrolide group, which has bacteriostatic effect in low concentrations and a bactericidal effect in high concentrations, mainly on Gram-positive microorganisms and some Gram-negative microorganisms and mycoplasmas, such as Mannheimia spp., Pasteurella spp., Actinomyces spp., Fusobacterium spp., Dichelobacter spp., Staphylococcus spp., and Mycoplasma spp. as well.
• Tilmicosin acts at the ribosomal level (50S-subunit); it inhibits protein synthesis in the bacterial cell. Tilmicosin has lipotropic properties, due to which it easily penetrates into organs and tissues, reaching high intracellular concentrations. This property allows you to effectively deal with respiratory diseases of animals.
• Tilmicosin reaches a maximum level in the blood 1 hour after a single subcutaneous injection of a dose of 10 mg per kg of animal body weight (1 ml of Tilmicon-300 per 30 kg b.w.). A high therapeutic concentration in the tissues of the body is retained for 3 days. Tilmicosin is concentrated in the lung tissue, penetrating intracellularly into Alveolar Macrophages. It is excreted from the body mainly with bile, and a small amount with urine.

Treatment of Cattle and Sheep with Interdigital Necrobacillosis, Hoof Rot (caused by Dichelobacter Nodosus and Fusobacterium Necrophorum), Acute Mastitis (caused by Staphylococcus Aureus and Mycoplasma Agalactiae), as well as with Respiratory Diseases caused by Mannheimia Haemolytica, Pasteurella Multocida, and other pathogens susceptible to Tilmicosin.

• Subcutaneously – once at a dose of 1 ml of the drug per 30 kg of animal body weight (10 mg of Tilmicosin per kg b.w.).
• Draw up the required dose of the drug from the vial into the syringe and disconnect the syringe from the needle, leaving the needle in the vial. If the treatment of a group of animals is planned, the needle must be left in a vial to draw the drug for subsequent injections. Fix the animal and insert another, separate needle subcutaneously, behind the Scapula. Connect the syringe to the needle and inject the drug into the base of the skin fold.
• When using the drug in lambs, it is important to accurately control body weight in order to avoid an overdose.
• If the dose of the injected drug exceeds 20 ml for Cattle or 2 ml for Sheep, it should be divided and injected into different places.

• The drug is not administered to animals with hypersensitivity to Tilmicosin or to other components of the drug.
• Do not administer intravenously or intramuscularly.
• Do not administer to lambs weighing less than 15 kg.
• Do not administer to Primates, Pigs, Horses, Donkeys, and Goats.

Side Effects:
Slight swelling may occur at the injection site, which does not require treatment and disappears within 5-8 days. In rare cases, a decrease in body weight, impaired coordination, and convulsions can be observed.

Administration During Pregnancy, Lactation:
The safety of the drug during pregnancy has not been established. The drug should be used with an assessment of the benefit/risk ratio by the responsible veterinarian.

Interaction With Other Drugs And Other Forms Of Interaction:
At simultaneous administration with other Macrolides and Lincomycin, cross-resistance can be observed.

Withdrawal Period:
Slaughter of the animals for meat is allowed in 70 days (Cattle), and in 42 days (Sheep) after the last treatment. Milk for human consumption is allowed in 36 days (Cattle) and in 18 days (Sheep) after the last treatment. Meat and milk received before the specified time should be disposed of or fed to non-producing animals, depending on the conclusion of the veterinarian.

Special Precautions For Persons And Service Staff That Use The Product:
Strictly follow the generally accepted rules of aseptic, personal hygiene, and safety when working with veterinary drugs, namely:
• The drug should be injected to animals only by a veterinarian.
• Never move the syringe, filled with the drug, together with a needle. The needle should be joined to the syringe only to fill or inject it. The rest of the time you should keep the syringe and needle in separate places.
• Do not use automatic devices to inject the drug.
• Do not carry out any manipulations with the drug yourself (alone).
• The drug is toxic to the Cardiovascular system when injected into humans. Toxicity is manifested due to the blockade of membrane Calcium Channels. If the drug was entered into any person by accident, you must immediately consult a doctor, and take the bottle, box, or leaflet with you. Apply a cold compress (except ice) on the injection site. Avoid contact with eyes and skin. After using the drug, wash your hands thoroughly.

Glass vials closed with rubber stoppers under aluminum caps of 10, 50 and 100 ml.

Store in a dark place, out of the reach of children, at +5 to +25°.

S24 months. Once the vial is opened: 28 days if stored in a dark place at +5 to +25° С.